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MUTATIONS AND AMINO ACIDS VARIATIONS OF CYTOCHROME B IN 26 OVARIAN TUMOR TISSUES OF SENEGALESE WOMEN

Dieynaba Ba, Fatimata Mbaye, Sidy Ka, Malick Fall , Ahmadou Dem, Mbacké Sembène

Ovarian cancer is one of the most deadly gynecological cancers. Annual mortality in West Africa is estimated at 76.23% in 2012. To evaluate the implication of the cytochrome B somatic mutations in ovarian cancer among senegaleses women, we analyzed variability of Cytochrome B at twenty six patients with ovarian cancer by PCR-sequencing. Polymorphism, differentiation and genetic evolution of the cytochrome b were highlighted. Results reveal the existence of strong variability of tumours with genetic differentiation within healthy and cancerous tissues, within young and older patients and a moderate demographic evolution of rare mutations of the disease. Our results also show a significant intraindividual increase of Phenylalanine (66.6%), tyrosine (66.6%) and tryptophan (60%) in cancer tissues with different proportions. Chi2 tests performed showed significant p-values. Any increase in the rate of tryptophan, phenylalanine and tyrosin in cancerous tissues could be correlated with an increased risk of developing ovarian cancer.

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