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The Effectiveness of Ganciclovir Comparing with Combination Therapy Of Oxytetracycline HCl + Polymyxin B Sulfate in Herpetic Epithelial Keratitis

Oguz Guvenmez, Asim kayiklik

Background: Herpes simplex virus is a common keratitis agent. There are two different types of virus, type 1 and 2. Type 1 shows three main clinical pictures in cornea: epithelial herpetic keratitis, stromal keratitis, disciform keratitis.

Aims: The aim of this study is to reduce the duration of herpetic keratitis treatment, eliminate the risk of complications, minimize the cost of treatment, and increasing the quality of patients.

Study Design: Prospective study.

Material and Methods: Between January 2017 and January 2018, 29 patients with herpetic keratitis were included in the study. In the first group, the herpetic membrane was removed by a single shot on the herpetic lesion with the yag laser. Then topically oxytetracycline hydrochloride+polymyxin B sulfate was applied. The second group was treated with topical antiviral therapy (Ganciclovir). After treatment, daily follow-up of patients, vision, tonus, fundus diameters and recovery times were noted, and the data were compared statistically.

Results: In group I and group II, the age of the patients did not differ significantly (p> 0.05). In group I and group II, the gender distribution of the patients did not differ significantly (p>0.05). In Group I and Group II, the degree of vison did not differ significantly (p>0.05). In group I and group II, the examination findings were not significant (p>0.05). In group I and group II, recovery time was significantly different (p<0.05).

Conclusion: In our study, the duration of herpetic keratitis treatment was very short as 4.5 days and no significant difference was observed between control vision, tonus, fundus diameter parameters and antiviral topical treatment (p<0.05). Although this result of the treatment showed the same efficacy as the antiviral treatment, we proved this effectiveness in a very short time