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Analytical Determination of Buspirone Hydrochloride in Pure Solutions, Pharmaceutical Preparation and Urine Samples

Abdel-Ghani NT, Rizk MS and Mostafa M

Simple, rapid, sensitive, precise and accurate spectrophotometeric methods for the determination of Buspirone hydrochloride (Bu-HCl) in bulk samples, dosage form and in spiked urine samples were investigated. The methods are based on the formation of a yellow colored ion-associates due to the interaction between the examined drug with Picric acid (PA), Bromothymol blue (BTB), Alizarin red (AR) and Bactophenol red (BPR) reagents. A buffer solution had been used and the extraction was carried out using organic solvent, the ion associates exhibit absorption maxima at 410, 410, 430 and 423 nm of (Bu-HCl) with PA, BBT, AR and BPR respectively. (Bu-HCl) could be determined up to 42.5, 29.5, 73.8 and 105.5 μg mL-1, using PA, BBT, AR and BPR respectively. The optimum reaction conditions for quantitative analysis were investigated. In addition, the molar absorptivity and Sandell sensitivity were determined for the investigated drug. The correlation coefficient was ≥ 0.995 (n=6) with a relative standard deviation (RSD) ≤ 2.66 for five selected concentrations of the reagents. Therefore the concentration of Bu-HCl in its pharmaceutical formulations and spiked urine samples had been determined successfully.