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Application of UV-Spectroscopy and First Order Derivative Method for Determination of Tamsulosin Hydrochloride in Bulk and Tablets

S. B. Bari, A. R. Bakshi, P. S. Jain and S. J. Surana

Two simple, rapid, sensitive and accurate UV-Spectrophotometry and First order derivative methods have been developed for estimation of tamsulosin hydrochloride in bulk and tablets. Methanol: water (2:8) was used as a solvent. In UV spectrophotometric method absorbance of samples are recorded at 280 nm. In first order derivative method the amplitude of trough was recorded at 298 nm. Tamsulosin follows linearity in the concentration range of 10-90 μg/ml. Assay results were in good agreement with label claim. These method were validated statistically and recovery studies.