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Cytotoxic effect of Carvacrol on human cervical cancer cells

Mehdi SJ, Ahmad A, Irshad M, Manzoor N, Rizvi MMA

Carvacrol is a component of numerous aromatic plants which has been evaluated for substantial pharmacological properties. Although the carvacrol induced cytotoxicity has already been reported, but no such study have been made on human cervical cancer, HeLa and SiHa cells. Therefore, in the present study an attempt has been made to investigate the cytotoxic effect of carvacrol on cervical cancer cells. Cytotoxicity induced by carvacrol was determined by different assays like MTT assay and LDH assay. Apoptosis was measured by DNA fragmentation assay. The study clearly showed the dose dependent cytotoxic effect of carvacrol in HeLa and SiHa cells at an IC50 of 50 mg L-1 by both the cytotoxic assays respectively. The dying cells showed characteristics of apoptosis such as, DNA fragmentation. The data in the present study clearly demonstrated cytotoxic effects of carvacrol on human cervical cancer cells. Carvacrol could have a potential therapeutic significance in treating cancer.