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Dual Sword Role of Aspirin as anticancer through induced or inhibition of Autophagy through mTOR pathway

Walaa Fikry Elbossaty

Autophagy is a natural physiological lysosomal catabolic process in which many cellular mechanism including degradation, elimination of misfolded protein, and organs damaged under the effect of starvation, stress and tumor suppression. It is like a double-edged sword that can play either a protective or destructive role in cancer, so it becomes the most intensive strategy in treatment of cancer. Autophagy have numerous mechanisms in treatment and controlling of cancer, including up regulation of tumor suppressor genes / Downregulation of oncogenes, and that can lead to inhibition/induction of cancer development. Aspirin is an important drug over the centuries. It is used as an anticoagulant, analgesic, and antipyretic. However, recent studies have shown that aspirin has an effective role in the prevention of cancer.