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Effects of Delayed Release Microsphere of Exenatide on Peri-Implant Bone Response of Diabetic Rats

Wenjuan Zhou,Stefan Tangl,Fei Chi,Xilong Yue,Shutai Liu,Zhonghao Liu,Xiaohui Rausch-Fan*

Objectives: The aim of this study is to evaluate and compare the impact of delayed release microsphere of exenatide on dental implants treatment of diabetic rats.

Materials and methods: 6 male Zucker Diabetic Fatty (ZDF) rats were divided into three groups: GroupA, diabetic rats with dental implants (controls). Group B, diabetic rats treated with exenatide and implants placed simultaneously. Group C, diabetic rats treated with exenatide until serum glucose at a constant level and then implants were placed. Implants with surrounding bone tissues were harvested and bone responses were assessed by histomorphometric analysis.

Results: Osseointegration of all implants had proceeded, bone response to implant surface of one implant in group A was similar to that in group B and C, and implants were surrounded by dense, very compact bone, osteocytes were deposited in lamellar bone in group C.

Conclusion: The present study of dental implants with Diabetes mellitus suggested that the process of osseointegration is affected by diabetes, early osseointegration can be enhanced in individuals with well-controlled diabetes, but the included samples were too small to get a statistical conclusion, further well designed comparative studies are needed to explore the exact effect of diabetes and metabolic control on bone response to dental implants.