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Formulation, Evaluation and Mathematical Modelling of Clopidogrel Bisulphate & Aspirin Immediate Release Bilayer Tablets

Abdul Althaf S, Sailaja PB and Ashwin Kumar M

The use of a fixed-dose combination (Clopidogrel bisulphate and Aspirin) tablet instead of the individual administration of the two compounds is expected to be more convenient to patients (and thus to improve compliance) by limiting the number of tablets they need to take. Therefore, to improve patient compliance and to decrease the incidence of adverse effects and side effects, Clopidogrel bisulphate and Aspirin are together formulated as an immediate release bilayer tablet. This study is intended to produce an immediate release bilayer tablets using solid dispersion technique. The prepared tablets were evaluated and subjected to dissolution studies.