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Insulin Receptor Signaling Platform: A New Approach

Jesica Velle*

Insulin Receptor (IR) signaling is important for maintaining glucose homeostasis. Insulin resistance, type 2 diabetes, obesity, cancer, hypertension, and cardiovascular problems have all been linked to a malfunctioning and/or uncontrolled IR activation. The molecular mechanisms that mediate IR activation have become a popular topic of study in both science and medicine. The present state of knowledge about IR structure, function and signaling is summarized below, with a focus on the role of glycosylation and sialylation in IR activation.