உயிரியல் மற்றும் மருத்துவம்

சுருக்கம்

நோய்களுக்கு சிகிச்சையளிக்க பாரம்பரியமாகப் பயன்படுத்தப்படும் மூன்று தென்னாப்பிரிக்க தாவரங்களின் பைட்டோகெமிக்கல் ஸ்கிரீனிங், ஆக்ஸிஜனேற்ற, அழற்சி எதிர்ப்பு மற்றும் குளுக்கோஸ் பயன்பாட்டு செயல்பாடுகள்

ஓயின்லோலா ஓ. ஓலாகுன், என்கோபைல் எம். ம்கோலோ, எம்.ஏ மொகலே மற்றும் பீட் எச். கிங்

Medicinal plants are important in the treatment of human diseases. The medicinal properties of plants are attributed to the presence of secondary plant metabolites. Polyphenols, particularly fl avonoids, are phytochemicals that possess antioxidant and anti-infl ammatory activity, and modulate pathways involved in obesity and glucose metabolism. In folk medicine, a single plant may be used to treat various diseases owing to the presence of phytochemical varieties in plants. In this study, the acetone leaf extracts of Curtisia dentata, Pittosporum viridifl orum, and Portulacaria afra were investigated for total polyphenol and total fl avonoid content as well as for anti-infl ammatory, antioxidant, and glucose utilization activities by using standard methods. The C. dentata extract exhibited the highest polyphenols (125.12 ± 2.18 mg/g GAE) and fl avonoids (27.69 ± 4.98 mg/g QE). The P. viridifl orum extract exhibited the strongest DPPH radical antioxidant activity (IC50 value=12.94 ± 1.09 μg/ml) and anti-infl ammatory activity by inhibiting 5-lipoxygenase activity (IC50 value 5 46.50 ± 4.54 μg/ml). All extracts enhanced dose-dependent glucose utilization activity of muscle cells and adipocytes. P. viridifl orum enhanced the highest glucose utilization of C2C12 muscle cells (67.34 ± 0.51%), while C. dentata enhanced the highest glucose utilization of 3T3-L1 adipocytes (63.72 ± 0.48%) at the highest concentration of 500 μg/ml, with no signifi cant difference (p<0.05). Polyphenols may be responsible for the observed 3T3-L1 cells glucose utilization activity of C. dentata. However, the polyphenols alone may not be responsible for the antioxidant, anti-infl ammatory, and C2C12 cells glucose utilization activity of P. viridifl orum. To our knowledge, this is the fi rst study to demonstrate the glucose utilization potential of the species of medicinal plants.