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Substantive Fluoride Release from a New Fluoride Varnish Containing CXP

Jessica L Milburn ,Lori E Henrichs ,Rosalia L Banfield ,Marion J Stansell ,Kraig S Vandewalle *

Objective: A new fluoride varnish (Embrace™) containing xylitol-coated calcium and phosphate (CXP™) claims to release ten times more fluoride over a four-hour period than leading fluoride varnishes. The purpose of this study was to compare the quantity and rate of fluoride release from enamel of a newly marketed fluoride varnish compared to three other fluoride systems.

Study design: Human third molars were cut into sections and Embrace™, Enamel Pro®, Duraphat®, or Vanish™ fluoride varnish were applied to the enamel surfaces. Specimens were immersed in synthetic saliva which was replaced at tested intervals. The concentration of fluoride in ppm was measured after specified hourly intervals during the first week and then weekly until the limit of detection (LOD). Mean cumulative fluoride release and rate of release were analyzed with a one-way ANOVA/Tukey (α=0.05).

Results: Significant differences existed between groups (p<0.001). Mean cumulative fluoride release is Embrace™>Enamel Pro®>Duraphat®=Vanish™. Rate of fluoride depletion is Embrace™>Duraphat®=Enamel Pro®=Vanish™.

Conclusions: Embrace™ had the greatest initial fluoride release, exceeding ten times the release of a leading fluoride varnish in the first four hours; however, Embrace™ had the highest rate of fluoride depletion and lowest substantivity of all varnishes tested.